CMap Candidate Details

Structure:
CMap ID: C30998
Pert ID: BRD-K90027355
Compound Name: spironolactone
Targets: NR3C2
MoA: Mineralocorticoid receptor antagonist
SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]33CCC(=O)O3)[C@H]12
InchiKey: LXMSZDCAJNLERA-ZHYRCANASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1658 BRD-K90027355 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2228 BRD-K90027355 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2545 BRD-K90027355 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
39818 BRD-K90027355 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.94
40918 BRD-K90027355 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41241 BRD-K90027355 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41581 BRD-K90027355 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
49908 BRD-K90027355 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50075 BRD-K90027355 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50430 BRD-K90027355 HCC515 10 uM 6 h 0.24 1.0 0.11 0.39 1.39 2.17
50607 BRD-K90027355 HT29 10 uM 6 h 0.0 0.0 0.0 0.41 1.47 2.24
50695 BRD-K90027355 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.04
52752 BRD-K90027355 HEPG2 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53086 BRD-K90027355 MCF10A 30 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91459 BRD-K90027355 HUH7 8 uM 72 h 0.0 0.0 0.0 0.19 0.66 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).