CMap Candidate Details

Structure:
CMap ID: C00310
Pert ID: BRD-A12230535
Compound Name: nutlin-3
Targets: MDM2
MoA: MDM inhibitor
SMILES: COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
InchiKey: BDUHCSBCVGXTJM-UHFFFAOYSA-N
Compound Aliases: NUTLIN-3A

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1335 BRD-A12230535 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
8858 BRD-A12230535 A375 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9136 BRD-A12230535 A549 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9266 BRD-A12230535 AGS 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9569 BRD-A12230535 H1299 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9998 BRD-A12230535 HA1E 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10382 BRD-A12230535 HCT116 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11319 BRD-A12230535 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.36
11638 BRD-A12230535 NCIH508 40 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.74
11889 BRD-A12230535 NCIH596 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12465 BRD-A12230535 PC3 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12646 BRD-A12230535 SW480 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12981 BRD-A12230535 THP1 40 uM 6 h -0.23 -0.96 0.1 0.0 0.0 0.0
13128 BRD-A12230535 U937 40 uM 6 h -0.22 -0.91 0.05 0.0 0.0 0.0
13416 BRD-A12230535 VCAP 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90822 BRD-A12230535 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97331 BRD-A12230535 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
118562 BRD-A12230535 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118784 BRD-A12230535 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118911 BRD-A12230535 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122310 BRD-A12230535 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122504 BRD-A12230535 YAPC 0.04 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
130648 BRD-A12230535 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130688 BRD-A12230535 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130773 BRD-A12230535 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).