CMap Candidate Details

Structure:
CMap ID: C31067
Pert ID: BRD-K90239174
Compound Name: AMG-487
Targets: CXCR3
MoA: CCK receptor antagonist
SMILES: CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1
InchiKey: WQTKNBPCJKRYPA-OAQYLSRUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121770 BRD-K90239174 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121801 BRD-K90239174 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129763 BRD-K90239174 A375 0.08 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
129799 BRD-K90239174 HA1E 0.03 uM 24 h 0.32 1.33 0.84 0.0 0.0 0.0
129840 BRD-K90239174 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129923 BRD-K90239174 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
129966 BRD-K90239174 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130006 BRD-K90239174 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130051 BRD-K90239174 MDAMB231 2.22 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
130087 BRD-K90239174 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130122 BRD-K90239174 THP1 0.08 uM 24 h 0.32 1.33 0.84 0.0 0.0 0.0
130168 BRD-K90239174 YAPC 0.25 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).