CMap Candidate Details

Structure:
CMap ID: C31087
Pert ID: BRD-K90333595
Compound Name: phentolamine
Targets: ADRA1A; ADRA2A
MoA: Adrenergic receptor antagonist
SMILES: Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1
InchiKey: MRBDMNSDAVCSSF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4501 BRD-K90333595 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.58
5133 BRD-K90333595 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.29
37416 BRD-K90333595 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37757 BRD-K90333595 ASC 10 uM 24 h 0.23 0.94 0.06 0.25 0.88 0.19
37954 BRD-K90333595 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
38572 BRD-K90333595 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
38792 BRD-K90333595 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39018 BRD-K90333595 SKB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
90973 BRD-K90333595 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
127347 BRD-K90333595 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127421 BRD-K90333595 HA1E 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
127461 BRD-K90333595 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127510 BRD-K90333595 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127602 BRD-K90333595 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127643 BRD-K90333595 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127680 BRD-K90333595 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
135397 BRD-K90333595 HT29 2.22 uM 24 h 0.23 0.96 0.07 0.32 1.14 0.86
135435 BRD-K90333595 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
135469 BRD-K90333595 MCF??7.00 0.74 uM 24 h -0.32 -1.32 0.82 0.17 0.59 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).