CMap Candidate Details

Structure:
CMap ID: C31102
Pert ID: BRD-K90382497
Compound Name: GW-843682X
Targets: PLK3; PLK1
MoA: PLK inhibitor
SMILES: COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
InchiKey: JSKUWFIZUALZLX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
508 BRD-K90382497 BJAB 10 uM 24 h 0.28 1.15 0.32 0.29 1.02 0.48
543 BRD-K90382497 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
580 BRD-K90382497 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
645 BRD-K90382497 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
691 BRD-K90382497 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
739 BRD-K90382497 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
772 BRD-K90382497 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
814 BRD-K90382497 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
881 BRD-K90382497 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
922 BRD-K90382497 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
971 BRD-K90382497 TMD8 10 uM 4 h -0.2 -0.82 0.0 0.0 0.0 0.0
9005 BRD-K90382497 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9847 BRD-K90382497 H1299 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.13 1.0
9953 BRD-K90382497 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10325 BRD-K90382497 HCC515 10 uM 6 h -0.24 -0.98 0.13 0.0 0.0 0.0
11607 BRD-K90382497 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11866 BRD-K90382497 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12402 BRD-K90382497 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12895 BRD-K90382497 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13390 BRD-K90382497 U937 10 uM 6 h 0.27 1.13 0.28 0.0 0.0 0.0
13512 BRD-K90382497 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39819 BRD-K90382497 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40919 BRD-K90382497 NEU 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
41242 BRD-K90382497 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41582 BRD-K90382497 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
83102 BRD-K90382497 HEPG2 4 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
83368 BRD-K90382497 PC3 10 uM 24 h -0.2 -0.84 0.01 -0.33 -1.12 0.93
91557 BRD-K90382497 BT20 10 uM 6 h 0.29 1.22 0.47 0.0 0.0 0.0
91700 BRD-K90382497 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91729 BRD-K90382497 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
92426 BRD-K90382497 A549 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
92552 BRD-K90382497 HME1 3.33 uM 3 h 0.0 0.0 0.0 -0.27 -0.92 0.33
92574 BRD-K90382497 HS578T 10 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
92619 BRD-K90382497 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92651 BRD-K90382497 LNCAP 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92707 BRD-K90382497 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.49
95689 BRD-K90382497 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97923 BRD-K90382497 MCF??7.00 10 uM 6 h 0.23 0.98 0.09 -0.24 -0.8 0.12
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).