CMap Candidate Details

Structure:
CMap ID: C31130
Pert ID: BRD-K90524085
Compound Name: MY-5445
Targets: PDE5A
MoA: Phosphodiesterase inhibitor; Platelet aggregation inhibitor
SMILES: Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
InchiKey: CEHQLKSLMFIHBF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3065 BRD-K90524085 HA1E 10 uM 6 h -0.16 -0.67 0.0 -0.26 -0.88 0.25
3286 BRD-K90524085 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3559 BRD-K90524085 PC3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
3989 BRD-K90524085 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
41855 BRD-K90524085 A375 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.16
41986 BRD-K90524085 A549 10 uM 24 h -0.25 -1.04 0.21 -0.33 -1.11 0.91
42494 BRD-K90524085 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42804 BRD-K90524085 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43093 BRD-K90524085 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43362 BRD-K90524085 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.31
43669 BRD-K90524085 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43970 BRD-K90524085 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).