CMap Candidate Details

Structure:
CMap ID: C31240
Pert ID: BRD-K90868879
Compound Name: canagliflozin
Targets: SLC5A1; SLC5A2
MoA: Sodium/glucose cotransporter inhibitor
SMILES: Cc1ccc(cc1Cc1ccc(s1)-c1ccc(F)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InchiKey: XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128149 BRD-K90868879 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128238 BRD-K90868879 MCF10A 1.11 uM 24 h 0.26 1.08 0.21 -0.21 -0.7 0.03
128268 BRD-K90868879 MCF??7.00 3.33 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
128317 BRD-K90868879 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135761 BRD-K90868879 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
135822 BRD-K90868879 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
135861 BRD-K90868879 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135911 BRD-K90868879 HELA 0.74 uM 24 h 0.25 1.03 0.14 0.0 0.0 0.0
135951 BRD-K90868879 HT29 0.25 uM 24 h 0.21 0.87 0.01 -0.31 -1.05 0.69
136001 BRD-K90868879 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136066 BRD-K90868879 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136097 BRD-K90868879 THP1 0.03 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
136147 BRD-K90868879 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).