CMap Candidate Details

Structure:
CMap ID: C03127
Pert ID: BRD-K02265150
Compound Name: amoxapine
Targets: DRD1; DRD2; DRD3; DRD4; HTR2A; HTR6; SLC6A2; SLC6A4
MoA: Norepinephrine reputake inhibitor
SMILES: Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1
InchiKey: QWGDMFLQWFTERH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5749 BRD-K02265150 HCC515 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.87
6508 BRD-K02265150 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42258 BRD-K02265150 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42594 BRD-K02265150 HEPG2 10 uM 6 h -0.27 -1.14 0.42 0.28 0.99 0.4
43454 BRD-K02265150 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43761 BRD-K02265150 PHH 10 uM 24 h 0.22 0.92 0.04 -0.24 -0.82 0.15
91014 BRD-K02265150 HUH7 10 uM 72 h 0.18 0.73 0.0 0.28 0.99 0.39
122861 BRD-K02265150 HA1E 0.04 uM 24 h 0.25 1.03 0.13 0.26 0.92 0.25
122899 BRD-K02265150 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
122941 BRD-K02265150 HELA 1.11 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
122975 BRD-K02265150 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123024 BRD-K02265150 JURKAT 10 uM 24 h 0.24 1.0 0.1 0.0 0.0 0.0
123114 BRD-K02265150 MDAMB231 10 uM 24 h 0.3 1.24 0.53 -0.26 -0.87 0.23
123147 BRD-K02265150 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123185 BRD-K02265150 THP1 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
123217 BRD-K02265150 YAPC 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
131211 BRD-K02265150 A375 0.74 uM 24 h -0.33 -1.36 1.07 0.0 0.0 0.0
131247 BRD-K02265150 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
131361 BRD-K02265150 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131401 BRD-K02265150 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131439 BRD-K02265150 MCF??7.00 0.74 uM 24 h -0.25 -1.03 0.2 -0.36 -1.21 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).