CMap Candidate Details

Structure:
CMap ID: C00313
Pert ID: BRD-A12409803
Compound Name: orteronel
Targets: CYP17A1
MoA: Cytochrome P450 inhibitor; Androgen receptor antagonist; Androgen biosynthesis inhibitor
SMILES: CNC(=O)c1ccc2cc(ccc2c1)C1(O)CCn2cncc12
InchiKey: OZPFIJIOIVJZMN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8859 BRD-A12409803 A375 40 uM 24 h 0.27 1.12 0.26 -0.27 -0.9 0.29
9137 BRD-A12409803 A549 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9267 BRD-A12409803 AGS 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9570 BRD-A12409803 H1299 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9999 BRD-A12409803 HA1E 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10226 BRD-A12409803 HCC515 40 uM 24 h 0.29 1.2 0.42 0.0 0.0 0.0
10650 BRD-A12409803 HEPG2 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10893 BRD-A12409803 HT29 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11225 BRD-A12409803 MCF??7.00 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11320 BRD-A12409803 NCIH2073 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11890 BRD-A12409803 NCIH596 40 uM 6 h 0.25 1.03 0.13 0.23 0.83 0.11
12188 BRD-A12409803 NOMO1 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12550 BRD-A12409803 PC3 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13129 BRD-A12409803 U937 40 uM 6 h 0.24 1.02 0.13 -0.3 -1.01 0.56
13523 BRD-A12409803 VCAP 40 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).