CMap Candidate Details

Structure:
CMap ID: C31312
Pert ID: BRD-K91111634
Compound Name: rotigotine
Targets: DRD1; DRD2; DRD3; DRD4; DRD5
MoA: Dopamine receptor agonist
SMILES: CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
InchiKey: KFQYTPMOWPVWEJ-INIZCTEOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127743 BRD-K91111634 A375 0.125 uM 24 h -0.21 -0.87 0.02 -0.24 -0.82 0.15
127787 BRD-K91111634 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127823 BRD-K91111634 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127867 BRD-K91111634 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127941 BRD-K91111634 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127994 BRD-K91111634 MCF10A 3.33 uM 24 h -0.18 -0.77 0.0 0.0 0.0 0.0
128078 BRD-K91111634 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
135568 BRD-K91111634 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135613 BRD-K91111634 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135659 BRD-K91111634 JURKAT 0.08 uM 24 h 0.23 0.96 0.08 -0.27 -0.92 0.31
135696 BRD-K91111634 MCF??7.00 2.22 uM 24 h 0.26 1.09 0.23 -0.31 -1.04 0.66
135719 BRD-K91111634 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).