CMap Candidate Details

Structure:
CMap ID: C31323
Pert ID: BRD-K91159026
Compound Name: telcagepant
Targets: CALCRL; RAMP1
MoA: Calcitonin antagonist
SMILES: Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F
InchiKey: CGDZXLJGHVKVIE-DNVCBOLYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127740 BRD-K91159026 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127784 BRD-K91159026 A549 1.11 uM 24 h 0.24 1.0 0.11 0.35 1.23 1.19
127820 BRD-K91159026 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
127864 BRD-K91159026 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127899 BRD-K91159026 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
127938 BRD-K91159026 HUVEC 1.11 uM 24 h 0.31 1.31 0.75 0.0 0.0 0.0
127991 BRD-K91159026 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128027 BRD-K91159026 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128077 BRD-K91159026 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135565 BRD-K91159026 HELA 0.01 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
135656 BRD-K91159026 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135718 BRD-K91159026 PC3 0.08 uM 24 h -0.16 -0.68 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).