CMap Candidate Details

Structure:
CMap ID: C31361
Pert ID: BRD-K91301684
Compound Name: noscapine
Targets: SIGMAR1
MoA: Tubulin inhibitor; Bradykinin receptor antagonist
SMILES: COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]1N(C)CCc2cc3OCOc3c(OC)c12
InchiKey: AKNNEGZIBPJZJG-QZTJIDSGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3067 BRD-K91301684 HA1E 10 uM 6 h 0.19 0.79 0.0 -0.28 -0.94 0.37
3406 BRD-K91301684 HCC515 10 uM 6 h 0.0 0.0 0.0 0.2 0.72 0.02
3890 BRD-K91301684 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45050 BRD-K91301684 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45336 BRD-K91301684 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.05
45857 BRD-K91301684 MCF??7.00 10 uM 6 h 0.22 0.91 0.03 -0.24 -0.81 0.14
46160 BRD-K91301684 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
46475 BRD-K91301684 PHH 10 uM 24 h 0.31 1.3 0.68 0.0 0.0 0.0
46803 BRD-K91301684 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127350 BRD-K91301684 A375 0.37 uM 24 h 0.21 0.88 0.02 0.3 1.06 0.58
127390 BRD-K91301684 A549 3.33 uM 24 h -0.22 -0.9 0.05 0.31 1.09 0.67
127513 BRD-K91301684 JURKAT 1.11 uM 24 h 0.28 1.16 0.35 -0.35 -1.18 1.14
127554 BRD-K91301684 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127605 BRD-K91301684 PC3 0.04 uM 24 h -0.16 -0.66 0.0 0.22 0.79 0.07
127645 BRD-K91301684 THP1 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
127683 BRD-K91301684 YAPC 0.04 uM 24 h 0.21 0.89 0.02 0.26 0.92 0.25
135368 BRD-K91301684 HELA 0.08 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
135400 BRD-K91301684 HT29 2.22 uM 24 h -0.22 -0.92 0.06 -0.33 -1.1 0.85
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).