CMap Candidate Details

Structure:
CMap ID: C31402
Pert ID: BRD-K91456750
Compound Name: sacubitril
Targets: MME
MoA: Neprilysin inhibitor
SMILES: CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O
InchiKey: PYNXFZCZUAOOQC-UTKZUKDTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127343 BRD-K91456750 A375 3.33 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
127416 BRD-K91456750 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
127504 BRD-K91456750 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127550 BRD-K91456750 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127570 BRD-K91456750 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127598 BRD-K91456750 PC3 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.04
127640 BRD-K91456750 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127674 BRD-K91456750 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135344 BRD-K91456750 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135364 BRD-K91456750 HELA 0.25 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
135393 BRD-K91456750 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).