CMap Candidate Details

Structure:
CMap ID: C31484
Pert ID: BRD-K91696562
Compound Name: orantinib
Targets: FGFR1; FGFR2; KDR; PDGFRA; PDGFRB; AURKA; AURKB
MoA: FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: Cc1[nH]c(C=C2C(=O)Nc3ccccc23)c(C)c1CCC(O)=O
InchiKey: NHFDRBXTEDBWCZ-NTEUORMPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33588 BRD-K91696562 A375 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
33857 BRD-K91696562 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34210 BRD-K91696562 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34714 BRD-K91696562 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.85
34990 BRD-K91696562 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35227 BRD-K91696562 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35356 BRD-K91696562 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35637 BRD-K91696562 NEU 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
35865 BRD-K91696562 NPC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.72
36115 BRD-K91696562 PC3 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.38
36381 BRD-K91696562 PHH 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
36682 BRD-K91696562 SKB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.5
37017 BRD-K91696562 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).