CMap Candidate Details

Structure:
CMap ID: C31487
Pert ID: BRD-K91701654
Compound Name: U-0126
Targets: MAP2K1; MAP2K2
MoA: MEK inhibitor
SMILES: NC(Sc1ccccc1N)=C(C#N)/C(C#N)=C(/N)Sc1ccccc1N
InchiKey: DVEXZJFMOKTQEZ-MJZABRMRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33727 BRD-K91701654 A375 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
33945 BRD-K91701654 A549 10 uM 6 h -0.29 -1.2 0.55 0.37 1.32 1.71
34211 BRD-K91701654 ASC 10 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.19
34445 BRD-K91701654 HA1E 10 uM 6 h 0.29 1.2 0.43 0.0 0.0 0.0
34715 BRD-K91701654 HCC515 10 uM 6 h 0.0 0.0 0.0 0.31 1.08 0.66
34991 BRD-K91701654 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.75
35228 BRD-K91701654 HT29 10 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.76
35357 BRD-K91701654 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
35638 BRD-K91701654 NEU 10 uM 24 h 0.29 1.19 0.42 0.24 0.84 0.13
35866 BRD-K91701654 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
36012 BRD-K91701654 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36382 BRD-K91701654 PHH 10 uM 24 h 0.23 0.98 0.09 -0.22 -0.73 0.04
36683 BRD-K91701654 SKB 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
36894 BRD-K91701654 VCAP 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).