CMap Candidate Details

Structure:
CMap ID: C31554
Pert ID: BRD-K91900765
Compound Name: VX-745
Targets: MAPK14
MoA: P38 MAPK inhibitor
SMILES: Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1
InchiKey: VEPKQEUBKLEPRA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33608 BRD-K91900765 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34446 BRD-K91900765 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34992 BRD-K91900765 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.2 0.71 0.02
36383 BRD-K91900765 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36684 BRD-K91900765 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36895 BRD-K91900765 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91834 BRD-K91900765 HS578T 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.81
91867 BRD-K91900765 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91920 BRD-K91900765 MDAMB231 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91951 BRD-K91900765 SKBR3 2.22 uM 24 h 0.0 0.0 0.0 -0.46 -1.53 15.35
94445 BRD-K91900765 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94481 BRD-K91900765 ASC 0.37 uM 24 h -0.21 -0.89 0.03 0.28 0.99 0.4
94549 BRD-K91900765 CD34 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94596 BRD-K91900765 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94640 BRD-K91900765 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94690 BRD-K91900765 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94744 BRD-K91900765 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94791 BRD-K91900765 HT29 0.12 uM 24 h 0.2 0.85 0.0 0.3 1.07 0.62
94836 BRD-K91900765 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94889 BRD-K91900765 JURKAT 10 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
94935 BRD-K91900765 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95015 BRD-K91900765 NEU 0.12 uM 24 h -0.25 -1.06 0.24 -0.22 -0.76 0.07
95053 BRD-K91900765 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
95162 BRD-K91900765 SHSY5Y 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95234 BRD-K91900765 SKL 3.33 uM 24 h 0.16 0.66 0.0 0.22 0.78 0.07
95272 BRD-K91900765 THP1 10 uM 24 h -0.25 -1.02 0.19 0.0 0.0 0.0
96959 BRD-K91900765 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).