CMap Candidate Details

Structure:
CMap ID: C31578
Pert ID: BRD-K92000912
Compound Name: AM-251
Targets: CNR1
MoA: Cannabinoid receptor antagonist
SMILES: Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
InchiKey: BUZAJRPLUGXRAB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2943 BRD-K92000912 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3409 BRD-K92000912 HCC515 10 uM 6 h 0.28 1.15 0.34 0.0 0.0 0.0
3562 BRD-K92000912 PC3 10 uM 24 h 0.26 1.08 0.22 0.32 1.13 0.84
3892 BRD-K92000912 VCAP 10 uM 24 h -0.3 -1.26 0.72 0.24 0.86 0.16
22005 BRD-K92000912 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22356 BRD-K92000912 A549 10 uM 6 h 0.24 0.99 0.1 0.0 0.0 0.0
23188 BRD-K92000912 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.89 0.27
23476 BRD-K92000912 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23654 BRD-K92000912 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39825 BRD-K92000912 ASC 10 uM 24 h 0.26 1.07 0.2 -0.26 -0.86 0.21
40923 BRD-K92000912 NEU 10 uM 24 h -0.22 -0.9 0.05 -0.36 -1.23 1.25
41247 BRD-K92000912 NPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
41588 BRD-K92000912 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).