CMap Candidate Details

Structure:
CMap ID: C31601
Pert ID: BRD-K92049597
Compound Name: triamterene
Targets: SCNN1A; SCNN1B; SCNN1G
MoA: Sodium channel blocker
SMILES: Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
InchiKey: FNYLWPVRPXGIIP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4502 BRD-K92049597 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5134 BRD-K92049597 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
37759 BRD-K92049597 ASC 10 uM 24 h -0.28 -1.17 0.48 -0.32 -1.07 0.76
37956 BRD-K92049597 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.09
38574 BRD-K92049597 NPC 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
38794 BRD-K92049597 PHH 10 uM 24 h 0.23 0.95 0.06 -0.28 -0.95 0.41
39020 BRD-K92049597 SKB 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
127747 BRD-K92049597 A375 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
127792 BRD-K92049597 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127826 BRD-K92049597 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127872 BRD-K92049597 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127902 BRD-K92049597 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127946 BRD-K92049597 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.01
127999 BRD-K92049597 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.02
128030 BRD-K92049597 MCF??7.00 0.37 uM 24 h -0.22 -0.91 0.05 0.24 0.84 0.13
128081 BRD-K92049597 YAPC 0.04 uM 24 h -0.21 -0.87 0.02 0.22 0.77 0.05
135573 BRD-K92049597 HELA 0.03 uM 24 h 0.21 0.87 0.01 -0.37 -1.24 1.3
135664 BRD-K92049597 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135722 BRD-K92049597 PC3 0.03 uM 24 h -0.18 -0.73 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).