CMap Candidate Details
Structure:
| CMap ID: | C31646 |
| Pert ID: | BRD-K92213669 |
| Compound Name: | lomitapide |
| Targets: | MTTP |
| MoA: | Microsomal trigylceride transfer protein inhibitor |
| SMILES: | FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12 |
| InchiKey: | MBBCVAKAJPKAKM-UHFFFAOYSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 127341 | BRD-K92213669 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127414 | BRD-K92213669 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127457 | BRD-K92213669 | HELA | 10 uM | 24 h | -0.15 | -0.61 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127502 | BRD-K92213669 | JURKAT | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127569 | BRD-K92213669 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127596 | BRD-K92213669 | PC3 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127638 | BRD-K92213669 | THP1 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127672 | BRD-K92213669 | YAPC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135342 | BRD-K92213669 | A549 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.39 | 1.37 | 2.11 |
| 135391 | BRD-K92213669 | HT29 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135431 | BRD-K92213669 | MCF10A | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |