CMap Candidate Details

Structure:
CMap ID: C31700
Pert ID: BRD-K92428153
Compound Name: mycophenolate-mofetil
Targets: IMPDH1; IMPDH2
MoA: IMPDH inhibitor; IMPase inhibitor; Immunosuppressant; Dehydrogenase inhibitor; Hydroxycarboxylic acid receptor agonist
SMILES: COc1c(C)c2COC(=O)c2c(O)c1CC=C(/C)CCC(=O)OCCN1CCOCC1
InchiKey: RTGDFNSFWBGLEC-SYZQJQIISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4260 BRD-K92428153 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4599 BRD-K92428153 HCC515 10 uM 6 h 0.24 1.0 0.11 0.31 1.1 0.7
4729 BRD-K92428153 PC3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
5135 BRD-K92428153 VCAP 10 uM 6 h 0.0 0.0 0.0 0.46 1.61 2.39
37199 BRD-K92428153 A375 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.18
37417 BRD-K92428153 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37761 BRD-K92428153 ASC 10 uM 24 h -0.16 -0.66 0.0 0.25 0.87 0.18
37958 BRD-K92428153 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38228 BRD-K92428153 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38575 BRD-K92428153 NPC 10 uM 24 h 0.23 0.98 0.09 -0.43 -1.44 15.35
38795 BRD-K92428153 PHH 10 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
87288 BRD-K92428153 BJAB 0.125 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
87364 BRD-K92428153 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87414 BRD-K92428153 K562 0.125 uM 24 h -0.18 -0.76 0.0 0.33 1.16 0.91
87462 BRD-K92428153 KMS34 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
87526 BRD-K92428153 MINO 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
87566 BRD-K92428153 NALM6 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
87616 BRD-K92428153 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87667 BRD-K92428153 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 -0.17 -0.58 0.0
87718 BRD-K92428153 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87765 BRD-K92428153 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87821 BRD-K92428153 THP1 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
87851 BRD-K92428153 TMD8 0.04 uM 3 h 0.24 1.01 0.11 -0.27 -0.9 0.28
91195 BRD-K92428153 HUH7 8 uM 72 h -0.19 -0.81 0.0 -0.24 -0.81 0.13
128413 BRD-K92428153 HEK293 3.33 uM 24 h 0.27 1.12 0.26 -0.28 -0.94 0.37
128468 BRD-K92428153 HELA 10 uM 24 h 0.28 1.15 0.32 0.0 0.0 0.0
128522 BRD-K92428153 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
128578 BRD-K92428153 MCF10A 0.37 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
128616 BRD-K92428153 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128749 BRD-K92428153 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136280 BRD-K92428153 HT29 0.03 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).