CMap Candidate Details

Structure:
CMap ID: C31716
Pert ID: BRD-K92446736
Compound Name: zatebradine
Targets: HCN4; HCN1; HCN3; HCN2
MoA: HCN channel blocker
SMILES: COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
InchiKey: KEDQCFRVSHYKLR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3069 BRD-K92446736 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.44 -1.47 15.35
3288 BRD-K92446736 HCC515 10 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
3564 BRD-K92446736 PC3 10 uM 24 h 0.37 1.52 1.45 -0.36 -1.2 1.18
3894 BRD-K92446736 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39226 BRD-K92446736 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39372 BRD-K92446736 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39828 BRD-K92446736 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40118 BRD-K92446736 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40535 BRD-K92446736 MCF??7.00 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
41251 BRD-K92446736 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41590 BRD-K92446736 SKB 10 uM 24 h 0.2 0.84 0.0 0.31 1.1 0.68
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).