CMap Candidate Details

Structure:
CMap ID: C31749
Pert ID: BRD-K92571446
Compound Name: WZ-3105
Targets: CLK2; CSNK1E; FLT3; ULK1
MoA: CLK inhibitor
SMILES: CC(C)n1cnc2c(Nc3cccc(NC(=O)C=C)c3)nc(N[C@H]3CC[C@@H](CC3)N(C)C)nc12
InchiKey: DGEBYERMQBTMHV-IRJFHVNHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91559 BRD-K92571446 BT20 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91589 BRD-K92571446 HS578T 0.08 uM 24 h -0.27 -1.11 0.38 -0.27 -0.9 0.28
91628 BRD-K92571446 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91669 BRD-K92571446 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
91719 BRD-K92571446 MDAMB231 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91781 BRD-K92571446 SKBR3 0.08 uM 6 h -0.18 -0.75 0.0 0.0 0.0 0.0
91985 BRD-K92571446 A375 0.12 uM 24 h -0.32 -1.32 0.85 0.0 0.0 0.0
92058 BRD-K92571446 HA1E 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92089 BRD-K92571446 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92180 BRD-K92571446 HT29 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92330 BRD-K92571446 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).