CMap Candidate Details

Structure:
CMap ID: C31809
Pert ID: BRD-K92778217
Compound Name: mefenamic-acid
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: Cc1cccc(Nc2ccccc2C(O)=O)c1C
InchiKey: HYYBABOKPJLUIN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1412 BRD-K92778217 A375 0.125 uM 6 h -0.2 -0.85 0.01 -0.27 -0.92 0.33
1414 BRD-K92778217 HEK293T 0.125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3070 BRD-K92778217 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3289 BRD-K92778217 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3652 BRD-K92778217 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3895 BRD-K92778217 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44630 BRD-K92778217 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
45052 BRD-K92778217 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45338 BRD-K92778217 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45597 BRD-K92778217 HT29 10 uM 6 h 0.24 0.99 0.1 0.0 0.0 0.0
45859 BRD-K92778217 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
46161 BRD-K92778217 NPC 10 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
46476 BRD-K92778217 PHH 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
46805 BRD-K92778217 SKB 10 uM 24 h 0.3 1.24 0.53 0.37 1.3 1.55
91216 BRD-K92778217 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).