CMap Candidate Details

Structure:
CMap ID: C31894
Pert ID: BRD-K92984783
Compound Name: melperone
Targets: DRD2; HTR2A
MoA: Serotonin receptor antagonist; Dopamine receptor antagonist
SMILES: CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1
InchiKey: DKMFBWQBDIGMHM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2144 BRD-K92984783 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2447 BRD-K92984783 PC3 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.17
25545 BRD-K92984783 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39834 BRD-K92984783 ASC 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.01
40124 BRD-K92984783 HEPG2 10 uM 6 h -0.3 -1.25 0.7 0.0 0.0 0.0
41257 BRD-K92984783 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41595 BRD-K92984783 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128371 BRD-K92984783 A549 0.04 uM 24 h 0.24 0.98 0.09 -0.36 -1.22 1.24
128420 BRD-K92984783 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
128471 BRD-K92984783 HELA 1.11 uM 24 h -0.31 -1.28 0.77 0.23 0.82 0.1
128493 BRD-K92984783 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
128530 BRD-K92984783 JURKAT 10 uM 24 h -0.22 -0.93 0.07 -0.27 -0.92 0.33
128623 BRD-K92984783 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128703 BRD-K92984783 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
136164 BRD-K92984783 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.06
136210 BRD-K92984783 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136303 BRD-K92984783 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136331 BRD-K92984783 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
136380 BRD-K92984783 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).