CMap Candidate Details

Structure:
CMap ID: C31966
Pert ID: BRD-K93208532
Compound Name: apremilast
Targets: PDE4A; PDE4B; PDE4C; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
InchiKey: IMOZEMNVLZVGJZ-QGZVFWFLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128102 BRD-K93208532 A375 10 uM 24 h 0.31 1.29 0.66 0.0 0.0 0.0
128128 BRD-K93208532 A549 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
128180 BRD-K93208532 HT29 0.37 uM 24 h -0.31 -1.27 0.74 -0.38 -1.28 1.45
128205 BRD-K93208532 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
128284 BRD-K93208532 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
135794 BRD-K93208532 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135839 BRD-K93208532 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135879 BRD-K93208532 HELA 2.22 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
135968 BRD-K93208532 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
136019 BRD-K93208532 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.59
136047 BRD-K93208532 PC3 2.22 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
136080 BRD-K93208532 THP1 2.22 uM 24 h -0.28 -1.16 0.45 0.31 1.1 0.7
136114 BRD-K93208532 YAPC 0.03 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).