CMap Candidate Details

Structure:
CMap ID: C32040
Pert ID: BRD-K93460210
Compound Name: lamotrigine
Targets: SCN1A; SCN2A; SCN3A
MoA: Sodium channel blocker; Serotonin receptor antagonist
SMILES: Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
InchiKey: PYZRQGJRPPTADH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1451 BRD-K93460210 NPC 6.66 uM 24 h 0.2 0.81 0.0 -0.27 -0.91 0.31
3293 BRD-K93460210 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25447 BRD-K93460210 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39838 BRD-K93460210 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40127 BRD-K93460210 HEPG2 10 uM 6 h 0.3 1.25 0.56 0.0 0.0 0.0
40934 BRD-K93460210 NEU 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
41599 BRD-K93460210 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
91125 BRD-K93460210 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
128376 BRD-K93460210 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128426 BRD-K93460210 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128498 BRD-K93460210 HT29 0.125 uM 24 h 0.0 0.0 0.0 -0.18 -0.61 0.0
128536 BRD-K93460210 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
128588 BRD-K93460210 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
128629 BRD-K93460210 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128676 BRD-K93460210 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.97
128709 BRD-K93460210 THP1 0.37 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
128757 BRD-K93460210 YAPC 3.33 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
136170 BRD-K93460210 A375 0.08 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.03
136215 BRD-K93460210 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136256 BRD-K93460210 HELA 0.08 uM 24 h 0.19 0.8 0.0 0.38 1.35 1.72
136336 BRD-K93460210 MCF??7.00 0.01 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).