CMap Candidate Details

Structure:
CMap ID: C32105
Pert ID: BRD-K93658967
Compound Name: aloisine
Targets: CDK2
MoA: CDK inhibitor; GSK-3 inhibitor; CFTR channel agonist
SMILES: CCCCc1c([nH]c2nccnc12)c3ccc(O)cc3
InchiKey: PRIGRJPRGZCFAS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2948 BRD-K93658967 HA1E 10 uM 24 h 0.25 1.04 0.15 0.3 1.07 0.64
3411 BRD-K93658967 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3569 BRD-K93658967 PC3 10 uM 24 h 0.18 0.77 0.0 0.29 1.03 0.49
3901 BRD-K93658967 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
39235 BRD-K93658967 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39376 BRD-K93658967 A549 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
39842 BRD-K93658967 ASC 10 uM 24 h -0.3 -1.23 0.64 0.29 1.02 0.48
40131 BRD-K93658967 HEPG2 10 uM 6 h -0.22 -0.91 0.05 -0.24 -0.81 0.13
40389 BRD-K93658967 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.9
40665 BRD-K93658967 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
41262 BRD-K93658967 NPC 10 uM 24 h 0.22 0.91 0.03 0.26 0.91 0.24
41603 BRD-K93658967 SKB 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).