CMap Candidate Details

Structure:
CMap ID: C32148
Pert ID: BRD-K93779381
Compound Name: ingenol-mebutate
Targets: PRKCA; PRKCD
MoA: PKC activator
SMILES: CC=C(C)C(=O)O[C@H]1C(C)=C[C@@]23[C@H](C)C[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]12O)C3=O)C4(C)C
InchiKey: VDJHFHXMUKFKET-WDUFCVPESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128104 BRD-K93779381 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128182 BRD-K93779381 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
128208 BRD-K93779381 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
128255 BRD-K93779381 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
128287 BRD-K93779381 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128330 BRD-K93779381 PC3 0.04 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
128347 BRD-K93779381 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135771 BRD-K93779381 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135797 BRD-K93779381 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135842 BRD-K93779381 HEK293 0.74 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
135882 BRD-K93779381 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.5 -1.7 15.65
135971 BRD-K93779381 JURKAT 0.08 uM 24 h -0.23 -0.95 0.09 -0.4 -1.33 1.74
136117 BRD-K93779381 YAPC 0.03 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).