CMap Candidate Details

Structure:
CMap ID: C32168
Pert ID: BRD-K93869735
Compound Name: taltirelin
Targets: TRHR
MoA: Thyrotropin releasing hormone receptor agonist
SMILES: CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
InchiKey: LQZAIAZUDWIVPM-SRVKXCTJSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128127 BRD-K93869735 A549 10 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
128162 BRD-K93869735 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128204 BRD-K93869735 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128254 BRD-K93869735 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128283 BRD-K93869735 MDAMB231 1.11 uM 24 h 0.25 1.02 0.13 -0.22 -0.75 0.06
135752 BRD-K93869735 A375 0.03 uM 24 h -0.25 -1.05 0.22 0.0 0.0 0.0
135793 BRD-K93869735 HA1E 0.25 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
135878 BRD-K93869735 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135930 BRD-K93869735 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
135967 BRD-K93869735 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
136046 BRD-K93869735 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136079 BRD-K93869735 THP1 0.01 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
136113 BRD-K93869735 YAPC 0.01 uM 24 h -0.33 -1.37 1.08 0.0 0.0 0.0
136407 BRD-K93869735 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).