CMap Candidate Details

Structure:
CMap ID: C32301
Pert ID: BRD-K94293891
Compound Name: suvorexant
Targets: HCRTR1; HCRTR2
MoA: Orexin receptor antagonist
SMILES: C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1
InchiKey: JYTNQNCOQXFQPK-MRXNPFEDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128382 BRD-K94293891 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128437 BRD-K94293891 HEK293 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
128478 BRD-K94293891 HELA 0.37 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
128547 BRD-K94293891 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128594 BRD-K94293891 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
128639 BRD-K94293891 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128719 BRD-K94293891 THP1 10 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
136179 BRD-K94293891 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136224 BRD-K94293891 HA1E 0.08 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
136289 BRD-K94293891 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
136343 BRD-K94293891 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
136364 BRD-K94293891 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136385 BRD-K94293891 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).