CMap Candidate Details

Structure:
CMap ID: C32349
Pert ID: BRD-K94436377
Compound Name: diosmin
Targets: AHR
MoA: Capillary stabilizing agent; Aryl hydrocarbon receptor agonist
SMILES: COc1ccc(cc1O)-c1cc(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2o1
InchiKey: GZSOSUNBTXMUFQ-YFAPSIMESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128211 BRD-K94436377 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128290 BRD-K94436377 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
135755 BRD-K94436377 A375 0.74 uM 24 h -0.2 -0.84 0.0 0.0 0.0 0.0
135773 BRD-K94436377 A549 0.03 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
135800 BRD-K94436377 HA1E 0.01 uM 24 h -0.29 -1.2 0.56 -0.32 -1.07 0.75
135844 BRD-K94436377 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135885 BRD-K94436377 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135933 BRD-K94436377 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135974 BRD-K94436377 JURKAT 0.74 uM 24 h 0.3 1.23 0.5 -0.36 -1.22 1.24
136022 BRD-K94436377 MCF??7.00 0.03 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
136051 BRD-K94436377 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
136082 BRD-K94436377 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136120 BRD-K94436377 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).