CMap Candidate Details

Structure:
CMap ID: C32352
Pert ID: BRD-K94441233
Compound Name: mevastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
InchiKey: AJLFOPYRIVGYMJ-INTXDZFKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1667 BRD-K94441233 HA1E 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
2014 BRD-K94441233 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2235 BRD-K94441233 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24507 BRD-K94441233 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24629 BRD-K94441233 A549 10 uM 24 h -0.18 -0.75 0.0 -0.3 -1.0 0.55
25451 BRD-K94441233 VCAP 10 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
39844 BRD-K94441233 ASC 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
40134 BRD-K94441233 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40392 BRD-K94441233 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40542 BRD-K94441233 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
40940 BRD-K94441233 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41265 BRD-K94441233 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41606 BRD-K94441233 SKB 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
90961 BRD-K94441233 HUH7 8 uM 72 h -0.22 -0.91 0.05 0.0 0.0 0.0
95613 BRD-K94441233 U2OS 4 uM 24 h -0.22 -0.9 0.04 0.23 0.83 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).