CMap Candidate Details

Structure:
CMap ID: C32374
Pert ID: BRD-K94512704
Compound Name: spiramide
Targets: HTR1A; HTR2A
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: Fc1ccc(OCCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)cc1
InchiKey: FJUKDAZEABGEIH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5239 BRD-K94512704 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5376 BRD-K94512704 HA1E 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
5698 BRD-K94512704 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6303 BRD-K94512704 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6604 BRD-K94512704 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39530 BRD-K94512704 A549 10 uM 6 h 0.19 0.8 0.0 0.0 0.0 0.0
39845 BRD-K94512704 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40393 BRD-K94512704 HT29 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
40667 BRD-K94512704 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40941 BRD-K94512704 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41266 BRD-K94512704 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41607 BRD-K94512704 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53417 BRD-K94512704 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
53539 BRD-K94512704 HUH7 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53751 BRD-K94512704 PHH 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).