CMap Candidate Details

Structure:
CMap ID: C03239
Pert ID: BRD-K02590140
Compound Name: O-2050
Targets: CNR1
MoA: Cannabinoid receptor antagonist
SMILES: CC1=CC[C@@H]2[C@@H](C1)c3c(O)cc(CC#CCCCNS(=O)(=O)C)cc3OC2(C)C
InchiKey: DJTGGIYZQHHLGJ-RTBURBONSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1722 BRD-K02590140 HA1E 10 uM 6 h 0.0 0.0 0.0 0.3 1.06 0.59
1866 BRD-K02590140 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2258 BRD-K02590140 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2587 BRD-K02590140 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41702 BRD-K02590140 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42043 BRD-K02590140 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42261 BRD-K02590140 ASC 10 uM 24 h -0.22 -0.9 0.04 0.34 1.19 1.01
42597 BRD-K02590140 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.09 0.82
42902 BRD-K02590140 HT29 10 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
43146 BRD-K02590140 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
43457 BRD-K02590140 NPC 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.28
43763 BRD-K02590140 PHH 10 uM 24 h -0.24 -1.0 0.14 0.32 1.14 0.87
44044 BRD-K02590140 SKB 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
99971 BRD-K02590140 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.18 -0.62 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).