CMap Candidate Details

Structure:
CMap ID: C32456
Pert ID: BRD-K94830329
Compound Name: ataluren
Targets: DMD
MoA: CFTR channel agonist; Dystrophin stimulant
SMILES: OC(=O)c1cccc(c1)-c1noc(n1)-c1ccccc1F
InchiKey: OOUGLTULBSNHNF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50438 BRD-K94830329 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51081 BRD-K94830329 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128384 BRD-K94830329 A549 10 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
128408 BRD-K94830329 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128439 BRD-K94830329 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
128549 BRD-K94830329 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128641 BRD-K94830329 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
128682 BRD-K94830329 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128721 BRD-K94830329 THP1 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
128767 BRD-K94830329 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
136181 BRD-K94830329 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136262 BRD-K94830329 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136290 BRD-K94830329 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136312 BRD-K94830329 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136344 BRD-K94830329 MCF??7.00 2.22 uM 24 h -0.18 -0.74 0.0 -0.28 -0.94 0.38
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).