CMap Candidate Details

Structure:
CMap ID: C32457
Pert ID: BRD-K94832621
Compound Name: Y-134
Targets: ESR1; ESR2
MoA: Estrogen receptor antagonist
SMILES: CC(C)N1CCN(CC1)c1ccc(cc1)C(=O)c1c(sc2cc(O)ccc12)-c1ccc(O)cc1
InchiKey: LQEOPHGPHCWOAC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1669 BRD-K94832621 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2015 BRD-K94832621 HCC515 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.28
2237 BRD-K94832621 PC3 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
2719 BRD-K94832621 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39239 BRD-K94832621 A375 10 uM 6 h -0.23 -0.96 0.1 -0.26 -0.89 0.26
39378 BRD-K94832621 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39847 BRD-K94832621 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40136 BRD-K94832621 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40395 BRD-K94832621 HT29 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.15
40668 BRD-K94832621 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40943 BRD-K94832621 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41268 BRD-K94832621 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41609 BRD-K94832621 SKB 10 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).