CMap Candidate Details

Structure:
CMap ID: C00325
Pert ID: BRD-A12994259
Compound Name: pomalidomide
Targets: CRBN; TNF
MoA: Angiogenesis inhibitor; Tumor necrosis factor production inhibitor
SMILES: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
InchiKey: UVSMNLNDYGZFPF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96930 BRD-A12994259 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122244 BRD-A12994259 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122342 BRD-A12994259 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122355 BRD-A12994259 MCF10A 3.33 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
122466 BRD-A12994259 THP1 10 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
130550 BRD-A12994259 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130585 BRD-A12994259 HA1E 0.74 uM 24 h 0.25 1.05 0.17 0.34 1.19 1.02
130618 BRD-A12994259 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130659 BRD-A12994259 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.58
130759 BRD-A12994259 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130780 BRD-A12994259 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
130829 BRD-A12994259 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).