CMap Candidate Details

Structure:
CMap ID: C32630
Pert ID: BRD-K95412502
Compound Name: istaroxime
Targets: ATP1A1
MoA: ATPase inhibitor
SMILES: C[C@]12CC[C@H]3[C@@H](CC(=O)[C@H]4CC(CC[C@]34C)=NOCCN)[C@@H]1CCC2=O
InchiKey: MPYLDWFDPHRTEG-PAAYLBSLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95678 BRD-K95412502 U2OS 10 uM 48 h 0.24 0.99 0.09 0.4 1.42 2.2
96352 BRD-K95412502 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
96423 BRD-K95412502 PC3 1.11 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
128143 BRD-K95412502 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128188 BRD-K95412502 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128231 BRD-K95412502 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128310 BRD-K95412502 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135817 BRD-K95412502 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135856 BRD-K95412502 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.13
135905 BRD-K95412502 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135994 BRD-K95412502 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
136032 BRD-K95412502 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136094 BRD-K95412502 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136140 BRD-K95412502 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).