CMap Candidate Details

Structure:
CMap ID: C32746
Pert ID: BRD-K95739795
Compound Name: tetrabenazine
Targets: SLC18A2
MoA: Vesicular monoamine transporter inhibitor
SMILES: COc1cc2CCN3C[C@H](CC(C)C)C(=O)C[C@H]3c2cc1OC
InchiKey: MKJIEFSOBYUXJB-HOCLYGCPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6817 BRD-K95739795 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7733 BRD-K95739795 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.22
8738 BRD-K95739795 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98165 BRD-K95739795 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98448 BRD-K95739795 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128390 BRD-K95739795 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
128445 BRD-K95739795 HEK293 1.11 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
128481 BRD-K95739795 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128555 BRD-K95739795 JURKAT 0.04 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
128597 BRD-K95739795 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
128647 BRD-K95739795 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128684 BRD-K95739795 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128727 BRD-K95739795 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128772 BRD-K95739795 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
136231 BRD-K95739795 HA1E 0.74 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
136294 BRD-K95739795 HT29 0.08 uM 24 h 0.26 1.07 0.19 0.0 0.0 0.0
136348 BRD-K95739795 MCF??7.00 0.03 uM 24 h 0.25 1.04 0.14 -0.24 -0.81 0.14
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).