CMap Candidate Details

Structure:
CMap ID: C32755
Pert ID: BRD-K95773607
Compound Name: darifenacin
Targets: CHRM1; CHRM2; CHRM3; CHRM4; CHRM5
MoA: Acetylcholine receptor antagonist
SMILES: NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c1ccccc1)c1ccccc1
InchiKey: HXGBXQDTNZMWGS-RUZDIDTESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96626 BRD-K95773607 A375 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
96694 BRD-K95773607 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128134 BRD-K95773607 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128166 BRD-K95773607 HEK293 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
128184 BRD-K95773607 HT29 10 uM 24 h -0.28 -1.15 0.44 -0.31 -1.04 0.68
128215 BRD-K95773607 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
128257 BRD-K95773607 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128294 BRD-K95773607 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
135804 BRD-K95773607 HA1E 0.74 uM 24 h -0.24 -0.99 0.14 0.0 0.0 0.0
135889 BRD-K95773607 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135978 BRD-K95773607 JURKAT 2.22 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
136085 BRD-K95773607 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136124 BRD-K95773607 YAPC 0.01 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).