CMap Candidate Details

Structure:
CMap ID: C32803
Pert ID: BRD-K95880107
Compound Name: PH-797804
Targets: MAPK14
MoA: P38 MAPK inhibitor
SMILES: CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O
InchiKey: KCAJXIDMCNPGHZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128108 BRD-K95880107 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128219 BRD-K95880107 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
128298 BRD-K95880107 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128352 BRD-K95880107 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135775 BRD-K95880107 A549 0.08 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
135808 BRD-K95880107 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
135848 BRD-K95880107 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
135893 BRD-K95880107 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135939 BRD-K95880107 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135982 BRD-K95880107 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136027 BRD-K95880107 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136057 BRD-K95880107 PC3 2.22 uM 24 h -0.2 -0.81 0.0 0.0 0.0 0.0
136128 BRD-K95880107 YAPC 2.22 uM 24 h 0.21 0.88 0.02 -0.29 -0.98 0.49
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).