CMap Candidate Details

Structure:
CMap ID: C32813
Pert ID: BRD-K95901403
Compound Name: XL-147
Targets: PIK3CA; PIK3CD; PIK3CG
MoA: PI3K inhibitor
SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1Nc1ccc2nsnc2c1
InchiKey: MQMKRQLTIWPEDM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33948 BRD-K95901403 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34216 BRD-K95901403 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34719 BRD-K95901403 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34997 BRD-K95901403 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.45 -1.52 15.35
35485 BRD-K95901403 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35641 BRD-K95901403 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35870 BRD-K95901403 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36387 BRD-K95901403 PHH 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
36689 BRD-K95901403 SKB 10 uM 24 h 0.0 0.0 0.0 0.52 1.84 2.9
36899 BRD-K95901403 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
95420 BRD-K95901403 U2OS 0.12 uM 48 h 0.0 0.0 0.0 -0.37 -1.24 1.3
97307 BRD-K95901403 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128409 BRD-K95901403 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128446 BRD-K95901403 HEK293 0.37 uM 24 h 0.26 1.09 0.22 0.29 1.01 0.46
128482 BRD-K95901403 HELA 10 uM 24 h 0.31 1.28 0.64 0.0 0.0 0.0
128508 BRD-K95901403 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128556 BRD-K95901403 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128648 BRD-K95901403 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128728 BRD-K95901403 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128773 BRD-K95901403 YAPC 10 uM 24 h 0.0 0.0 0.0 0.28 0.97 0.36
136185 BRD-K95901403 A375 2.22 uM 24 h -0.29 -1.22 0.61 -0.4 -1.34 1.85
136315 BRD-K95901403 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136369 BRD-K95901403 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).