CMap Candidate Details

Structure:
CMap ID: C33082
Pert ID: BRD-K96720755
Compound Name: relcovaptan
Targets: AVPR1A
MoA: Vasopressin receptor antagonist
SMILES: COc1ccc(cc1OC)S(=O)(=O)N1[C@@H](C(=O)N2CCC[C@H]2C(N)=O)[C@](O)(c2cc(Cl)ccc12)c1ccccc1Cl
InchiKey: CEBYCSRFKCEUSW-NAYZPBBASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2020 BRD-K96720755 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
2574 BRD-K96720755 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39861 BRD-K96720755 ASC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
40148 BRD-K96720755 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.01
40955 BRD-K96720755 NEU 10 uM 24 h -0.2 -0.82 0.0 0.24 0.85 0.14
41281 BRD-K96720755 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41623 BRD-K96720755 SKB 10 uM 24 h 0.23 0.95 0.06 -0.23 -0.78 0.09
128397 BRD-K96720755 A549 0.125 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.33
128457 BRD-K96720755 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128514 BRD-K96720755 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128567 BRD-K96720755 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
128659 BRD-K96720755 MDAMB231 0.04 uM 24 h 0.32 1.34 0.89 0.0 0.0 0.0
128691 BRD-K96720755 PC3 0.125 uM 24 h -0.34 -1.4 1.14 -0.28 -0.94 0.38
128739 BRD-K96720755 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136196 BRD-K96720755 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136241 BRD-K96720755 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136274 BRD-K96720755 HELA 2.22 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
136319 BRD-K96720755 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.19
136352 BRD-K96720755 MCF??7.00 0.74 uM 24 h 0.34 1.41 1.03 0.0 0.0 0.0
136392 BRD-K96720755 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.22 0.76 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).