CMap Candidate Details

Structure:
CMap ID: C33165
Pert ID: BRD-K97045029
Compound Name: pranlukast
Targets: CYSLTR1; CYSLTR2
MoA: Leukotriene receptor antagonist
SMILES: O=C(Nc1cccc2c1oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1
InchiKey: NBQKINXMPLXUET-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91037 BRD-K97045029 HUH7 6.66 uM 72 h -0.38 -1.59 15.35 0.0 0.0 0.0
128400 BRD-K97045029 A549 0.04 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
128460 BRD-K97045029 HEK293 0.37 uM 24 h -0.23 -0.97 0.11 -0.24 -0.82 0.15
128516 BRD-K97045029 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128570 BRD-K97045029 JURKAT 0.04 uM 24 h -0.28 -1.15 0.43 0.27 0.96 0.34
128604 BRD-K97045029 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128613 BRD-K97045029 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
128662 BRD-K97045029 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128780 BRD-K97045029 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
136199 BRD-K97045029 A375 0.03 uM 24 h -0.32 -1.34 0.98 0.22 0.77 0.06
136244 BRD-K97045029 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136277 BRD-K97045029 HELA 0.01 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
136373 BRD-K97045029 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).