CMap Candidate Details

Structure:
CMap ID: C00333
Pert ID: BRD-A13188892
Compound Name: doxazosin
Targets: ADRA1D; ADRA1B; ADRA1A
MoA: Adrenergic receptor antagonist
SMILES: COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1
InchiKey: RUZYUOTYCVRMRZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50974 BRD-A13188892 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52232 BRD-A13188892 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
91246 BRD-A13188892 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
122251 BRD-A13188892 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122361 BRD-A13188892 MCF10A 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
122474 BRD-A13188892 THP1 10 uM 24 h 0.36 1.52 1.44 0.0 0.0 0.0
130554 BRD-A13188892 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130589 BRD-A13188892 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
130625 BRD-A13188892 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130666 BRD-A13188892 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130706 BRD-A13188892 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130761 BRD-A13188892 MCF??7.00 0.25 uM 24 h -0.24 -1.0 0.15 -0.25 -0.83 0.17
130782 BRD-A13188892 MDAMB231 2.22 uM 24 h 0.38 1.58 1.51 0.31 1.11 0.73
130835 BRD-A13188892 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).