CMap Candidate Details

Structure:
CMap ID: C33300
Pert ID: BRD-K97472745
Compound Name: gestrinone
Targets: ESR1; AR; PGR
MoA: Progesterone receptor antagonist
SMILES: CC[C@]12C=CC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(O)C#C
InchiKey: BJJXHLWLUDYTGC-ANULTFPQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91096 BRD-K97472745 HUH7 10 uM 72 h -0.17 -0.71 0.0 0.0 0.0 0.0
95369 BRD-K97472745 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95478 BRD-K97472745 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
128404 BRD-K97472745 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128466 BRD-K97472745 HEK293 0.04 uM 24 h 0.2 0.84 0.0 -0.29 -0.97 0.46
128490 BRD-K97472745 HELA 10 uM 24 h 0.23 0.96 0.08 -0.27 -0.9 0.29
128576 BRD-K97472745 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128668 BRD-K97472745 MDAMB231 10 uM 24 h 0.29 1.21 0.47 0.0 0.0 0.0
128747 BRD-K97472745 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128786 BRD-K97472745 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136202 BRD-K97472745 A375 0.74 uM 24 h 0.22 0.9 0.02 0.3 1.08 0.65
136246 BRD-K97472745 HA1E 0.03 uM 24 h 0.25 1.04 0.16 0.36 1.29 1.47
136301 BRD-K97472745 HT29 0.01 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
136325 BRD-K97472745 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136376 BRD-K97472745 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).