CMap Candidate Details

Structure:
CMap ID: C33359
Pert ID: BRD-K97688263
Compound Name: benzamil
Targets: SCNN1A; SCNN1B; SCNN1D; SCNN1G; SLC8A1; PKD2L1
MoA: Sodium channel blocker
SMILES: NC(NCc1ccccc1)=N/C(=O)c1nc(Cl)c(N)nc1N
InchiKey: KXDROGADUISDGY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7043 BRD-K97688263 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7735 BRD-K97688263 HCC515 10 uM 6 h 0.26 1.1 0.24 -0.29 -0.99 0.5
8853 BRD-K97688263 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91293 BRD-K97688263 HUH7 10 uM 72 h -0.19 -0.78 0.0 0.0 0.0 0.0
121771 BRD-K97688263 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121822 BRD-K97688263 MCF??7.00 10 uM 24 h 0.29 1.21 0.44 -0.23 -0.76 0.07
121849 BRD-K97688263 PC3 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
129765 BRD-K97688263 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129800 BRD-K97688263 HA1E 0.74 uM 24 h 0.24 0.99 0.09 -0.33 -1.11 0.9
129842 BRD-K97688263 HEK293 0.03 uM 24 h -0.22 -0.92 0.06 0.36 1.28 1.37
129900 BRD-K97688263 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129968 BRD-K97688263 MCF10A 2.22 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
130053 BRD-K97688263 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130124 BRD-K97688263 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130169 BRD-K97688263 YAPC 0.74 uM 24 h -0.28 -1.17 0.48 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).