CMap Candidate Details

Structure:
CMap ID: C33378
Pert ID: BRD-K97729603
Compound Name: pimecrolimus
Targets: FKBP1A
MoA: Calcineurin inhibitor
SMILES: CC[C@@H]1C=C(C)C[C@H](C)C[C@H](OC)[C@@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(C)=C[C@@H]1CC[C@@H](Cl)[C@@H](C1)OC
InchiKey: KASDHRXLYQOAKZ-RNZHFBRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127336 BRD-K97729603 A375 0.04 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
127381 BRD-K97729603 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127410 BRD-K97729603 HA1E 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
127456 BRD-K97729603 HELA 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
127484 BRD-K97729603 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127497 BRD-K97729603 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
127548 BRD-K97729603 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127567 BRD-K97729603 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127591 BRD-K97729603 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127634 BRD-K97729603 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127667 BRD-K97729603 YAPC 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).