CMap Candidate Details

Structure:
CMap ID: C33447
Pert ID: BRD-K97951054
Compound Name: BRD-K97951054
Targets: PIM1; AURKB
MoA: VEGFR inhibitor; Pim kinase inhibitor; Aurora kinase inhibitor
SMILES: Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12
InchiKey: AQZHBCDRWFMXIN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25764 BRD-K97951054 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26027 BRD-K97951054 A549 10 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
26522 BRD-K97951054 ASC 10 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
27140 BRD-K97951054 HCC515 10 uM 6 h -0.25 -1.05 0.24 -0.28 -0.94 0.37
27453 BRD-K97951054 HT29 10 uM 6 h -0.28 -1.15 0.44 0.0 0.0 0.0
27642 BRD-K97951054 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28080 BRD-K97951054 NEU 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
28401 BRD-K97951054 NPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
28552 BRD-K97951054 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29028 BRD-K97951054 PHH 10 uM 24 h -0.25 -1.05 0.23 -0.33 -1.12 0.96
29372 BRD-K97951054 SKB 10 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
29575 BRD-K97951054 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).