CMap Candidate Details

Structure:
CMap ID: C33453
Pert ID: BRD-K97963946
Compound Name: EMD-1214063
Targets: MET
MoA: Hepatocyte growth factor receptor inhibitor
SMILES: CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
InchiKey: AHYMHWXQRWRBKT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128124 BRD-K97963946 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128155 BRD-K97963946 A549 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.64
128176 BRD-K97963946 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128195 BRD-K97963946 HT29 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
128248 BRD-K97963946 MCF10A 1.11 uM 24 h 0.18 0.75 0.0 -0.36 -1.23 1.25
128327 BRD-K97963946 MDAMB231 10 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
135832 BRD-K97963946 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135922 BRD-K97963946 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136012 BRD-K97963946 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
136039 BRD-K97963946 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
136072 BRD-K97963946 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136102 BRD-K97963946 THP1 0.08 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.8
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).